Beilstein J. Org. Chem.2018,14, 11–24, doi:10.3762/bjoc.14.2
unravel the causes of, potential new detection methods for, and novel therapeutic strategies against, many disease states. In the last two decades, glyco-goldnanoparticles have emerged as one of several potential new tools for glycoscientists. Glyco-goldnanoparticles consist of the unique structural
combination of a gold nanoparticle core and an outer-shell comprising multivalent presentation of carbohydrates. The combination of the distinctive physicochemical properties of the gold core and the biological function/activity of the carbohydrates makes glyco-goldnanoparticles a valuable tool in
glycoscience. In this review we present recent advances made in the use of one type of click chemistry, namely the azide–alkyne Huisgen cycloaddition, for the functionalization of gold nanoparticles and their conversion to glyco-goldnanoparticles.
Keywords: azide–alkyne Huisgen cycloaddition; carbohydrates
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Graphical Abstract
Figure 1:
The three major methods for the synthesis of GAuNPs. (a) Direct reduction of an Au3+ salt in the pr...
Beilstein J. Org. Chem.2017,13, 1008–1021, doi:10.3762/bjoc.13.100
, Nanotechnology Lab., Via G. Fantoli 16/15, 20138 Milan, Italy 10.3762/bjoc.13.100 Abstract Glyco-goldnanoparticles combine in a single entity the peculiar properties of gold nanoparticles with the biological activity of carbohydrates. The result is an exciting nanosystem, able to mimic the natural multivalent
, gold can be easily and covalently decorated on its surface by exploiting the strong soft–soft interaction between a Au atom and sulfur [8]. Therefore, glyco-goldnanoparticles (GAuNPs) represent a smart, multimodal and versatile nanoplatform to develop carbohydrate-based nanotechnology and nanomedicine
systems.
The present review focuses its attention only toward the synthesis of gold-based nanoparticles coated with carbohydrates. A first introduction related to the main protocols to produce glyco-goldnanoparticles is followed by a section where the main parameters which should be taken into account
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Graphical Abstract
Figure 1:
Schematic overview on the glyco-gold nanoparticles synthetic approaches.